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December Newsletter: Page 4

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Dr. Matijevic

Professor Egon Matijević (the Victor K. LaMer Chair of Colloid and Surface Science at Clarkson University) poses with his book Fine Particles in Medicine and Pharmacy.

Distinguished University Professor Egon Matijević Carries Out Research about Uric Acid and Its Salts

Research on uric acid can be grouped into two categories. Most of the studies describe analytical methods for the determination of its concentration in urine and blood. Others deal with the precipitation of uric acid as ultrafine colloids or single crystals in order to develop a mechanism for the formation of uric acid kidney stones. Since no successful method was developed to produce uniform particles, in size and shape, of this acid and its salts, Distinguished University Professor Egon Matijević (the Victor K. LaMer Chair of Colloid and Surface Science at Clarkson University) took on this task. Uric acid and its ammonium, sodium, calcium, and barium salts were successfully prepared as uniform dispersions by precipitation in basic aqueous solutions.  The effects of the reactant concentrations, pH, and additives were evaluated in detail.  All prepared compounds appeared as needles or their aggregates (except for the platelets of the pure acid).  Electron micrographs showed that kidney stones consisted of such aggregates.  However, they were less regular in size and morphology. It is also interesting to note that the precipitated salt particles were chemically and morphologically unstable at low pH values.

This reference describes the work in detail:

Mohamed, Amr Ali and Matijević, Egon: “Preparation and characterization of uniform particles of uric acid and its salts,” Journal of Colloid and Interface Science, Vol. 392, 129-136 (Feb. 2013).  

The entire paper can be read at the following link.

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Professor Eunsu Paek Joins CAMP
Dr. Paek

Assistant Professor Eunsu Paek

Dr. Eunsu Paek joined the chemical and biomolecular engineering department at Clarkson University in 2015 as an assistant professor. She attended Seoul National University, where she obtained her Bachelor’s and Master’s degrees in the chemical and biological engineering department.  Then she earned a Ph.D. in chemical engineering from the University of Texas at Austin. Before joining Clarkson, she was a postdoctoral fellow in chemistry for two years at the UT Austin.

Professor Paek’s research focuses on developing theoretical foundations for guiding the rational design and synthesis of novel nanomaterials for energy and environmental applications. Her research utilizes molecular-level computer simulations to investigate fundamental properties and processes in various nanomaterials, such as interfacial phenomena, solution dynamics, chemical reactions, and phase transformations. Professor Paek’s research interests also lie in developing multiscale computational platforms that can incorporate the fundamental knowledge gained to larger scale simulations. She has written over 20 publications in professional journals, and has given over 30 invited and contributed talks in both the USA and Korea.