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Clarkson Senior Co-Publishes Research Linking Protein Production To Disease Treatment And Cancer Prevention

Daniel Marker, a resident of Wellsburg, N.Y., and a senior studying biomolecular science and pre-physical therapy in the Honors Program at Clarkson University, will be graduating this spring with more than a bachelor of science degree.

Marker is the co-author of two research papers that may explain why the contracting the Human Papillomavirus may cause an increased risk in contracting cervical cancer. The articles appear in the scientific journals Carcinogenesis and Molecular Cancer Therapeutics (in press).

The primary focus of Marker's research is to explain the effects of the protein, NF-kappa-B, on gene expression. When found in high amounts within cells, this protein causes cells to act as though they were cancerous, causing them to grow quickly and die slowly. As part of the study, Marker linked the Human Papillomavirus to an increased production of NF-kappa-B. If production of the protein can be linked to carcinogenesis, which is the process of tumor development, then finding a way to medicinally inhibit the production of the protein could be useful in treating the Human Papillomavirus, tumor development, and certain forms of cervical cancer.

"Hands-on experience in the lab is crucial to someone studying science, but it's even greater to be able to actually contribute to the scientific community as a student at the undergraduate level," said Marker. "Although I did not realize it at the time, during my freshman year I was learning techniques and concepts in the laboratory that could later be taught in 400-level courses. What I have learned here at Clarkson, and the way I have learned it is invaluable."

Marker plans to enter a medical or doctoral degree program after graduating from Clarkson.

[News directors and editors: For more information, contact Annie Harrison, Director of Media Relations, at 315-268-6764 or]

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