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Clarkson University & Columbia University Researchers Team to Unveil New Signaling Pathway

Researchers at the Clarkson University Biochemistry and Proteomics Laboratory, led by Prof. Costel Darie, have received the news that a manuscript has been accepted for publication in the Journal of Biological Chemistry.

The study investigated the receptor of a new pituitary hormone (Tumor Differentiation Factor, TDF) with differentiation activity on breast and prostate cancer cells. Based on their study, the TDF activates a possible novel pathway.

The hope is to ultimately unveil how this new hormone works. The researchers believe that TDF has anti-cancer activity and potential as a future treatment.
The study is a combination of unique sets of expertise, from protein chemistry and proteomics, to analytical biochemistry, cell biology and neuroscience -- a new direction for Clarkson.

It was performed in Darie’s lab in the Department of Chemistry & Biomolecular Science with support from Mary Ann Gawinowicz’s Protein Chemistry core facility at Columbia University.

Most of the work was performed by Izabela Sokolowska, a Ph.D. student in Darie’s lab.

Clarkson University launches leaders into the global economy. One in five alumni already leads as a CEO, VP or equivalent senior executive of a company. Located just outside the Adirondack Park in Potsdam, N.Y., Clarkson is a nationally recognized research university for undergraduates with select graduate programs in signature areas of academic excellence directed toward the world’s pressing issues. Through 50 rigorous programs of study in engineering, business, arts, sciences and health sciences, the entire learning-living community spans boundaries across disciplines, nations and cultures to build powers of observation, challenge the status quo, and connect discovery and engineering innovation with enterprise.

[News directors and editors: For more information, contact Annie Harrison, Director of Media Relations, at 315-268-6764 or]

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